Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia
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Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia
In vertebrate olfactory receptor neurons (ORNs), odorant-induced activation of the transduction cascade culminates in production of cyclic AMP, which opens cyclic nucleotide-gated channels in the ciliary membrane enabling Ca(2+) influx. The ensuing elevation of the intraciliary Ca(2+) concentration opens Ca(2+)-activated Cl(-) channels, which mediate an excitatory Cl(-) efflux from the cilia. I...
متن کاملOlfactory response termination involves Ca-ATPase in vertebrate olfactory receptor neuron cilia
Olfactory transduction takes place in the cilia of olfactory receptor neurons (ORNs) (for review see Kleene, 2008). The process begins with the activation of an odorant receptor in the ciliary membrane, followed by synthesis of cAMP through activation of adenylyl cyclase (Lowe et al., 1989) via a G protein–coupled cascade. The ensuing increase in cAMP concentration causes CNG channels to open (...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2010
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200910337